Key result
High adherence (96%) to antihypertensive therapy compared with lower adherence (59%) was associated with a reduced risk of coronary artery disease events (RR 0.90; 95% CI 0.84-0.95).
Why the study?
Does high adherence to antihypertensive agents reduce the incidence of coronary artery disease in patients without prior cardiovascular disease?
Population
83,267 patients aged 45-85 years without indication of cardiovascular disease, newly treated with…
Comparison
High adherence level to antihypertensive therapy vs Lower adherence level to antihypertensive therapy
Design
Case-control
Authors
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May support adherence promotion in primary prevention; leaves open causal confirmation by RCTs.
Case-Control (n=83,267)
Does high adherence to antihypertensive agents reduce the incidence of coronary artery disease in patients without prior cardiovascular disease?
Effect estimate: RR 0.90 (95% CI 0.84-0.95)
Better adherence to antihypertensive agents is associated with a significant reduction in the risk of developing coronary artery disease in primary prevention.
Perreault et al. (2009) conducted a case-control in Coronary artery disease (n=83,267). High adherence to antihypertensive agents vs. Lower adherence to antihypertensive agents was evaluated on Incidence of coronary artery disease (RR 0.90, 95% CI 0.84-0.95). High adherence (96%) to antihypertensive therapy compared with lower adherence (59%) was associated with a reduced risk of coronary artery disease events (RR 0.90; 95% CI 0.84-0.95).
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