Key result
High adherence (≥80%) to antihypertensive agents significantly decreased the risk of cerebrovascular disease compared with lower adherence (RR 0.78; 95% CI 0.70-0.87).
Why the study?
Does high adherence to antihypertensive agents reduce the incidence of cerebrovascular disease in hypertensive patients without prior cardiovascular disease?
Population
83,267 hypertensive patients, aged 45-85 years, initially free of cardiovascular disease, newly treated for…
Comparison
High adherence to antihypertensive drugs vs Lower adherence to antihypertensive drugs
Design
Case-control
Authors
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High adherence may lower cerebrovascular risk in primary prevention; leaves open causal confirmation in randomized trials.
Case-Control (n=83,267)
Does high adherence to antihypertensive agents reduce the incidence of cerebrovascular disease in hypertensive patients without prior cardiovascular disease?
Effect estimate: RR 0.78 (95% CI 0.70-0.87)
High adherence (≥80%) to antihypertensive therapy in primary prevention is associated with a 22% reduced risk of cerebrovascular disease in real-world practice.
Kettani et al. (2008) conducted a case-control in Hypertension (n=83,267). High adherence (≥80%) to antihypertensive agents vs. Lower adherence (<80%) to antihypertensive agents was evaluated on Incidence of cerebrovascular disease (RR 0.78, 95% CI 0.70-0.87). High adherence (≥80%) to antihypertensive agents significantly decreased the risk of cerebrovascular disease compared with lower adherence (RR 0.78; 95% CI 0.70-0.87).
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