Key result
Early discontinuation of antihypertensive drugs in primary prevention increased the risk of acute myocardial infarction (RR 1.15; 95% CI 1.00-1.33) and stroke (RR 1.28; 95% CI 1.15-1.45).
Why the study?
Does early discontinuation of antihypertensive drugs increase the risk of acute myocardial infarction or stroke in primary prevention patients?
Population
77,193 new users of antihypertensive drugs ≥ 18 years of age in the Netherlands, excluding those using AHT…
Comparison
Non-persistent use of antihypertensive drugs vs Persistent use of antihypertensive drugs
Design
Cohort
Follow-up
Up to 4 years
Authors
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Early discontinuation may raise MI/stroke risk in primary prevention; leaves open causality and should not yet change practice.
Cohort (n=77,193)
Yes
Does early discontinuation of antihypertensive drugs increase the risk of acute myocardial infarction or stroke in primary prevention patients?
Effect estimate: RR 1.15 for AMI; RR 1.28 for stroke (95% CI 1.00-1.33 for AMI; 1.15-1.45 for stroke)
Early discontinuation of antihypertensive therapy in primary prevention significantly increases the risk of subsequent acute myocardial infarction and stroke.
Breekveldt‐Postma et al. (2007) conducted a cohort in Hypertension (primary prevention) (n=77,193). Early discontinuation of antihypertensive drugs vs. Persistence with antihypertensive drugs was evaluated on Acute myocardial infarction (AMI) or stroke (RR 1.15 for AMI; RR 1.28 for stroke, 95% CI 1.00-1.33 for AMI; 1.15-1.45 for stroke). Early discontinuation of antihypertensive drugs in primary prevention increased the risk of acute myocardial infarction (RR 1.15; 95% CI 1.00-1.33) and stroke (RR 1.28; 95% CI 1.15-1.45).
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