Clinical Profile and Prognosis of Patients With Acute Decompensated Heart Failure Who Met the Obesity-Related Eligibility for Subcutaneous Semaglutide　― Findings From the CURE-HF Registry ―

Figures

• 

  Figure 1.. Study flowchart. ADHF, acute decompensated heart failure; BMI, body mass index.

• 

  Figure 2.. Histogram for body mass index. Red and blue lines have been drawn because the definition of semaglutide eligibility is body mass index (BMI) ≥27 kg/m2 along with ≥2 health problems related to obesity or BMI ≥35 kg/m2. Anything to the right of the red line indicates BMI ≥27 kg/m2, and anything to the right of the blue line indicates BMI ≥35 kg/m2.

• 

  Figure 3.. Kaplan-Meier curves based on semaglutide eligibility created by comparing the 2 groups for all-cause death (Upper left), cardiovascular (CV) death (Upper right), non-CV death (Lower left) and rehospitalization due to heart failure (HF) exacerbation (Lower right). The incidence rate is plotted on the vertical axis, and the passage of time after enrolment is plotted on the horizontal axis. Event incidence was significantly lower in semaglutide-eligible patients than in semaglutide non-eligible patients.

• 

  Figure 4.. After propensity score-matching by age and sex, Kaplan-Meier curves were created by comparing the 2 groups for all-cause death (Upper left), cardiovascular (CV) death (Upper right), non-CV death (Lower left) and rehospitalization due to heart failure (HF) exacerbation (Lower right). The incidence rate is plotted on the vertical axis, and the passage of time after enrolment is plotted on the horizontal axis. After propensity score-matching for age and sex, no significant differences were found between groups for the endpoints.

• 

  Figure 5.. Associations between BMI and incidence rate of all-cause death using restricted cubic spline curves. (A) unadjusted, (B) adjusted for age and sex, and (C) adjusted for age, sex, and BNP values. The incidence rate of all-cause death (events per 100 person-years) is shown on the left y-axis and BMI values on the x-axis. The solid curves depict the incidence with 95% confidence intervals for the estimates. Poisson models were used to estimate incidence rates. Histograms show the population distribution of BMI. BMI, body mass index; BNP, B-type natriuretic peptide.