Key result
Ischaemia-reperfusion induced local up-regulation of vasoconstrictor ETB receptors in the smooth muscle cells of coronary arteries in the post-ischaemic area.
Why the study?
Does heart ischaemia-reperfusion induce local up-regulation of vasoconstrictor ETB receptors in rat coronary arteries?
Population
Male Sprague-Dawley rats
Comparison
Heart ischaemia-reperfusion or permanent… vs Sham operation
Design
Preclinical
Follow-up
22 hours
Authors
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May identify ETB receptors as a therapeutic target post-ischaemia; leaves open translation from this animal model.
Does heart ischaemia-reperfusion induce local up-regulation of vasoconstrictor ETB receptors in rat coronary arteries?
Ischaemia-reperfusion induces local up-regulation of vasoconstrictor ETB receptors in the smooth muscle cells of coronary arteries in the post-ischaemic area.
Skovsted et al. (2014) studied Myocardial ischaemia. Heart ischaemia-reperfusion vs. Sham operation was evaluated on Endothelin receptor-mediated vasoconstriction and receptor protein levels. Ischaemia-reperfusion induced local up-regulation of vasoconstrictor ETB receptors in the smooth muscle cells of coronary arteries in the post-ischaemic area.
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