Key result
Changes in the phosphorylation states of key cardiac regulatory proteins, modulated by various kinase and phosphatase pathways, may underlie cardiac dysfunction in disease states.
Design
Review
Authors
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May guide mechanistic studies of cardiac dysfunction; leaves open whether targeting phosphorylation pathways alters clinical outcomes.
This review highlights the critical role of protein phosphorylation and dephosphorylation in regulating myocardial function and its pathophysiological implications in cardiac disease.
Stephen T. Rapundalo (1998) conducted a review in Cardiac dysfunction. Changes in the phosphorylation states of key cardiac regulatory proteins, modulated by various kinase and phosphatase pathways, may underlie cardiac dysfunction in disease states.
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