What does this research mean for the field?

Voltage-dependent slow calcium channels in cardiac muscle must be phosphorylated, a process regulated by cyclic AMP, to be available for voltage activation, thereby allowing extrinsic control by neurotransmitters and hormones. Novelty: ClaimNovelty.NOVEL_FINDING. Consensus alignment: ConsensusAlignment.NEUTRAL.

January 1, 1984Membrane Biochemistry

Hormonal and Neurotransmitter Regulation of Ca++Influx Through Voltage-Dependent Slow Channels in Cardiac Muscle Membrane

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Population

Myocardial cell membrane / cardiac muscle

Design

Review

Authors

NSNick SperelakisUniversity of Virginia

Discussion

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Implication

Explains cAMP-dependent cardiac Ca channel control; leaves open targeted therapies in arrhythmias.

Structured PICO

Population

Myocardial cell membrane / cardiac muscle

Intervention

Neurotransmitters, hormones, and autacoids affecting cyclic AMP levels

Outcome

Ca++ influx through voltage-dependent slow channels

Highlights the fundamental mechanism of cyclic AMP-mediated phosphorylation in regulating calcium influx through slow channels in cardiac muscle.

Cite This Study

Nick Sperelakis (1984) studied this question.

synapsesocial.com/papers/6a1709b2b082e78ad77bcd78 https://doi.org/10.3109/09687688409150275

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Hormonal and Neurotransmitter Regulation of Ca++Influx Through Voltage-Dependent Slow Channels in Cardiac Muscle Membrane

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Hormonal and Neurotransmitter Regulation of Ca++Influx Through Voltage-Dependent Slow Channels in Cardiac Muscle Membrane

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Also Consider

Also Consider