Key result
Single large K-complexes during stage 2 sleep were associated with significant increases in blood pressure and muscle sympathetic nerve activity burst area (median 9.0 vs 3.9 arbitrary units, P<0.03).
Population
8 healthy volunteers (3 men and 5 women, age 22-41 yr)
Design
Other
Authors
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K-complexes may contribute to sympathetic-mediated BP fluctuations in sleep; extends mechanistic understanding but leaves open clinical relevance.
Observational (n=8)
Absolute Event Rate: 9% vs 3.9%
p-value: p=<0.03
Sleep K-complexes are associated with temporary facilitation of sympathetic outflow and subsequent increases in blood pressure, independent of baroreflex modulation in approximately half of cases.
Tank et al. (2003) conducted an observational in Healthy volunteers (n=8). Sleep K-complexes vs. Baseline was evaluated on Area under the muscle sympathetic nerve activity burst (p=<0.03). Single large K-complexes during stage 2 sleep were associated with significant increases in blood pressure and muscle sympathetic nerve activity burst area (median 9.0 vs 3.9 arbitrary units, P<0.03).
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