Key result
Diabetic HFpEF emerges as a multisystem disorder driven by metabolic rewiring and inter-organ crosstalk.
Why the study?
The rising prevalence of obesity and diabetes has reshaped HFpEF into a multi-system disorder, creating a need to summarize metabolic rewiring and inter-organ crosstalk in diabetic HFpEF.
Design
Review
Authors
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May support systemic therapies in diabetic HFpEF; leaves open optimal targets for prospective trials.
Understanding the inter-organ crosstalk and metabolic rewiring in diabetic HFpEF highlights the need for systemic, personalized treatment strategies that target these multi-organ pathways.
Luo et al. (2025) conducted a review in Diabetic heart failure with preserved ejection fraction (HFpEF). Diabetic HFpEF is a multisystem disorder driven by metabolic rewiring and inter-organ crosstalk involving the heart, liver, gut, adipose tissue, and hematopoietic system.
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