Key result
This article reviews the mechanisms of cellular calcium regulation in cardiac myocytes, including sarcolemmal and intracellular transport systems, and their role in contractile activation.
Provides a comprehensive overview of cellular calcium regulation, transport systems, and contractile activation in cardiac myocytes.
May guide mechanistic interpretation of calcium modulators; leaves open clinical translation in HF and arrhythmias.
The sections in this article are: General Aspects of Cellular Calcium Regulation Ca Transport Systems Cytosolic Volume Conventions Ca Binding Sites and Buffering in Cardiac Myocytes Ca Requirements for Contractile Activation Simplified Kinetic Considerations During a Ca Transient Sarcolemmal Ca Transport Systems Ca Channels Na/Ca Exchange Sarcolemmal Ca‐ ATPase Intracellular Ca Transporters Sarcoplasmic Reticulum Ca‐ ATPase and Sarcoplasmic Reticulum Ca Content Sarcoplasmic Reticulum Ca Release Channels Mitochondrial Ca Transport Ca Removal from the Cytoplasm During Relaxation Relative Contributions of Ca Transporters Species, Developmental, and Temperature Dependence Ca Recycling from Mitochondria Back to the SR The Ca Supply that Activates Contraction Ca Influx vs SR Ca Release Fraction of SR Ca Released During a Twitch Perturbations of Cellular Ca Balance Rest‐Dependent Changes in Cellular and SR Ca Content Refilling Depleted Internal Ca Stores Rest‐Decay and Rest‐Potentiation of Twitches Force‐Frequency Relationships
No takes yet. Share an insight, caveat, or question.
Donald M. Bers (2002) conducted a review in Cellular Calcium Regulation in Cardiac Myocytes. This article reviews the mechanisms of cellular calcium regulation in cardiac myocytes, including sarcolemmal and intracellular transport systems, and their role in contractile activation.
Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context: