What is the clinical evidence from this study?

Study design: Meta-Analysis. Population: Insulin resistance. Intervention: Adipose tissue depots and obesity indices. Primary outcome: Correlation between HOMA-IR and visceral fat mass (r 0.570, 95% CI 0.424-0.687).

December 21, 2015Scientific ReportsOpen Access

Associations of Different Adipose Tissue Depots with Insulin Resistance: A Systematic Review and Meta-analysis of Observational Studies

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Key result

Visceral fat mass showed the strongest positive correlation with insulin resistance (HOMA-IR) among various adipose tissue depots, with a pooled correlation coefficient of 0.570.

Why the study?

Are different adipose tissue depots and obesity indices associated with insulin resistance in adults?

Population

Adults ≥19 years old without chronic conditions or with uncomplicated type 2 diabetes, from 40 observational…

Design

Meta-analysis

Authors

MZMingzhi ZhangSoochow University THTian HuTulane University SZShaoyan ZhangShanghai University of Traditional Chinese Medicine

Discussion

Member takes

Implication

Visceral fat assessment may refine insulin resistance risk stratification in adults; reinforces its primacy among adipose depots.

Study Design

Type

Meta-Analysis

Structured PICO

Are different adipose tissue depots and obesity indices associated with insulin resistance in adults?

Population

Adults ≥19 years old without chronic conditions (cancer, heart failure, chronic kidney disease, infectious disease) or with uncomplicated type 2 diabetes, from 40 observational studies comprising 56 populations.

Intervention

Adipose tissue depots and obesity indices (e.g., visceral fat mass, total fat mass, body mass index, waist circumference)

Outcome

Correlation with insulin resistance as measured by homeostatic model assessment of insulin resistance (HOMA-IR)surrogate

Main Result

Effect estimate: r 0.570 (95% CI 0.424-0.687)

Visceral fat mass has the strongest positive correlation with insulin resistance (HOMA-IR) among various adipose tissue depots and obesity indices, highlighting its importance as a metabolic risk marker.

Limitations

Only HOMA-IR was used as an index to measure insulin resistance without testing other methods.
Race/ethnicity was not well defined in some of the included studies.
Considerable heterogeneity was present in the meta-analyses.
Only used HOMA-IR as an index to measure insulin resistance
Race/ethnicity was not well defined in some of the included studies
Considerable heterogeneity presented in the meta-analyses

Cite This Study

Zhang et al. (2015) conducted a meta-analysis in Insulin resistance. Adipose tissue depots and obesity indices was evaluated on Correlation between HOMA-IR and visceral fat mass (r 0.570, 95% CI 0.424-0.687). Visceral fat mass showed the strongest positive correlation with insulin resistance (HOMA-IR) among various adipose tissue depots, with a pooled correlation coefficient of 0.570.

synapsesocial.com/papers/6a172e3be6fc0256052c271b https://doi.org/10.1038/srep18495

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Associations of Different Adipose Tissue Depots with Insulin Resistance: A Systematic Review and Meta-analysis of Observational Studies

Discussion

Member takes

Implication

Study Design

Structured PICO

Main Result

Limitations

Cite This Study

Associations of Different Adipose Tissue Depots with Insulin Resistance: A Systematic Review and Meta-analysis of Observational Studies

Discussion

Member takes

Implication

Study Design

Structured PICO

Main Result

Limitations

Cite This Study

Also Consider

Also Consider