The Prognostic Role of Mitral Valve Regurgitation Severity and Left Ventricle Function in Acute Heart Failure
Key result
Reduced LVEF, not MR severity, predicts ~44% higher 1-year mortality in acute heart failure.
- HR 1.44
- 95% CI 1.25-1.67
- P<0.001
- n=6,843
Why the study?
Data regarding the prognostic interplay between mitral regurgitation and left ventricular function in patients admitted with acute heart failure were scarce.
Does mitral regurgitation severity and left ventricular function predict mortality and recurrent heart failure hospitalization in patients admitted with acute heart failure?
Population
6843 patients admitted with AHF
Comparison
MR severity and LV function categories
Follow-up
1-year
Authors
Discussion
Loading...
Member takes
Implication
May inform LVEF-based mortality stratification in acute HF; leaves open MR's independent role in rehospitalization risk.
Study Design
Type
Cohort (n=6,843)
Structured PICO
Does mitral regurgitation severity and left ventricular function predict mortality and recurrent heart failure hospitalization in patients admitted with acute heart failure?
P
Population
6,843 patients admitted with acute heart failure (AHF), including 2,521 with LVEF ≤ 40% (reduced LVEF) and 4,322 with LVEF > 40% (preserved LVEF).
I
Intervention
≥moderate mitral regurgitation (MR)
C
Comparator
≤mild mitral regurgitation (MR)
O
Outcome
Mortality and recurrent heart failure hospitalization (re-HFH) at 1 yearhard clinical
Main Result
Effect estimate: HR 1.44 (95% CI 1.25-1.67)
p-value: p=<0.001
In acute heart failure, reduced LV function is the main determinant of 1-year mortality, whereas significant mitral regurgitation increases the risk of recurrent hospitalization regardless of LV function.
Cite This Study
Mazin et al. (2022) conducted a cohort in Acute Heart Failure (n=6,843). Reduced LVEF (≤ 40%) and/or ≥moderate mitral regurgitation vs. Preserved LVEF (> 40%) and ≤mild mitral regurgitation was evaluated on 1-year mortality (HR 1.44, 95% CI 1.25-1.67, p=<0.001). Reduced LVEF, but not mitral regurgitation severity, predicted 1-year mortality in acute heart failure (HR 1.44; 95% CI 1.25-1.67 for reduced LVEF with ≥moderate MR; P<0.001).