January 11, 2007European Heart Journal
Mitral regurgitation in myocardial infarction complicated by heart failure, left ventricular dysfunction, or both: prognostic significance and relation to ventricular size and function
Why the study?
Does baseline severity and progression of mitral regurgitation predict adverse cardiovascular outcomes in patients with heart failure or systolic dysfunction after myocardial infarction?
Population
496 patients with heart failure and/or systolic dysfunction after myocardial infarction who underwent…
Comparison
Baseline mitral regurgitation severity and… vs Lower grades of mitral regurgitation or no…
Design
Cohort
Follow-up
20 months
Authors
Discussion
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Member takes
Implication
Moderate-severe MR may aid risk stratification in post-MI HF; leaves open whether intervention improves outcomes.
Structured PICO
Does baseline severity and progression of mitral regurgitation predict adverse cardiovascular outcomes in patients with heart failure or systolic dysfunction after myocardial infarction?
P
Population
496 patients with heart failure and/or systolic dysfunction after myocardial infarction who underwent echocardiography at a median of 5 days after MI.
I
Intervention
Baseline mitral regurgitation (MR) severity (assessed by regurgitant jet area/left atrial area ratio) and progression of MR over 20 months.
C
Comparator
Lower grades of mitral regurgitation or no progression of mitral regurgitation.
O
Outcome
Total mortality, cardiovascular mortality, hospitalization for heart failure, and the composite of death or heart failure hospitalization.hard clinical
In patients with heart failure or left ventricular dysfunction post-myocardial infarction, moderate-to-severe mitral regurgitation and its progression are strong independent predictors of mortality and heart failure hospitalization.
Cite This Study
Amigoni et al. (2007) studied this question.