Key result
Mild and moderate-to-severe ischemic mitral regurgitation after myocardial infarction were associated with an increased risk of heart failure compared to no MR (HR 2.8 and 3.6, respectively; P<0.001).
Why the study?
Does ischemic mitral regurgitation increase the risk of heart failure in patients after myocardial infarction?
Population
1190 patients admitted for acute myocardial infarction
Comparison
Ischemic mitral regurgitation vs Patients without mitral regurgitation
Design
Cohort
Follow-up
median 24 months (range, 6-48 months)
Authors
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Post-MI ischemic MR may signal elevated HF risk even when mild; leaves open whether targeted intervention improves outcomes.
Cohort (n=1,190)
Does ischemic mitral regurgitation increase the risk of heart failure in patients after myocardial infarction?
Hazard Ratio: 2.8 (95% CI 1.8–4.2)
p-value: p=<.001
There is a graded independent association between the severity of ischemic mitral regurgitation and the development of heart failure after myocardial infarction, with even mild MR increasing risk.
Doron Aronson (2006) conducted a cohort in Acute myocardial infarction (n=1,190). Ischemic mitral regurgitation vs. No mitral regurgitation was evaluated on Heart failure (HR 2.8, 95% CI 1.8-4.2, p=<.001). Mild and moderate-to-severe ischemic mitral regurgitation after myocardial infarction were associated with an increased risk of heart failure compared to no MR (HR 2.8 and 3.6, respectively; P<0.001).
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