Key result
Four single-beat methods for calculating contractility showed unacceptably high limits of agreement (+/-2.6 to +/-3.8 mmHg/ml) compared with multiple-beat elastance and failed to predict increases.
Effect estimate: Average bias -0.3 to 0.5 mmHg/ml (95% CI +/-2.6 to +/-3.8 mmHg/ml)
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Single-beat contractility estimates should not replace multiple-beat elastance clinically; challenges consensus and leaves validation open.
Kjørstad et al. (2002) studied Left ventricular contractility assessment (n=37). Four single-beat methods for calculating contractility vs. Preload-varied multiple-beat elastance was evaluated on Agreement of single-beat contractility estimates with preload-varied multiple-beat elastance (Average bias -0.3 to 0.5 mmHg/ml, 95% CI +/-2.6 to +/-3.8 mmHg/ml). Four single-beat methods for calculating contractility showed unacceptably high limits of agreement (+/-2.6 to +/-3.8 mmHg/ml) compared with multiple-beat elastance and failed to predict increases.
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