November 9, 2004Neurology
Stroke risk profile, brain volume, and cognitive function
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Discussion
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Implication
Cohort study finds higher stroke risk scores associate with lower brain volume and reduced cognition in dementia-free adults, highlighting the impact of subclinical vascular damage.
Key Points
- To examine how stroke risk profiles relate to total cerebral brain volume and cognitive performance in individuals free of clinical stroke and dementia.
- Evaluated 1,841 stroke- and dementia-free participants (mean age 62 years; 857 men, 984 women) from the community-based Framingham Offspring Study cohort who underwent quantitative brain MRI and cognitive testing between 1999 and 2001.
- Used age- and sex-adjusted linear regression models to relate past (1991–1995) and recent (1998–2001) Framingham Stroke Risk Profile (FSRP) scores to total cerebral brain volume ratio (TCBVr) and education-adjusted neuropsychological test scores.
- Higher FSRP scores were inversely associated with total cerebral brain volume ratio.
- Greater TCBVr was significantly and positively associated with performance on tests of attention (Trails A), executive function (Trails B), and visuospatial function (visual reproduction, Hooper visual organization).
- TCBVr showed no significant association with performance on tests evaluating verbal memory or naming.
Cite This Study
Seshadri et al. (2004) studied this question.