August 1, 1999Archives of Neurology
Occurrence and Progression of Dementia in a Community Population Aged 75 Years and Older
Key result
Antihypertensive medication use at baseline was associated with a reduced incidence of dementia compared to no use (adjusted RR 0.7; 95% CI 0.6-1.0; P=0.03).
Why the study?
Does antihypertensive medication use reduce the occurrence and progression of dementia in a community population aged 75 years and older?
Population
1,810 persons aged 75 years and older in a community cohort, including 225 with prevalent dementia and 1,301…
Comparison
Antihypertensive medication use recorded for the… vs No antihypertensive medication use.
Design
Cohort
Follow-up
average 3 years
Authors
Discussion
Loading...
Member takes
Implication
The use of antihypertensive medications, particularly diuretics, is associated with a reduced incidence and slower progression of dementia in elderly individuals.
Study Design
Type
Cohort (n=1,810)
Structured PICO
Does antihypertensive medication use reduce the occurrence and progression of dementia in a community population aged 75 years and older?
P
Population
1,810 persons aged 75 years and older in a community cohort, including 225 with prevalent dementia and 1,301 without dementia at baseline.
I
Intervention
Antihypertensive medication use (including diuretics, calcium antagonists, or beta-blockers) recorded for the 2 weeks preceding baseline.
C
Comparator
No antihypertensive medication use.
O
Outcome
Occurrence (incidence) of dementia over an average period of 3 years.hard clinical
Main Result
Effect estimate: RR 0.7 (95% CI 0.6-1.0)
p-value: p=0.03
The use of antihypertensive medications, particularly diuretics, is associated with a reduced incidence and slower progression of dementia in elderly individuals.
Cite This Study
Guo et al. (1999) conducted a cohort in Dementia (n=1,810). Antihypertensive medication vs. No antihypertensive medication was evaluated on Incidence of dementia (RR 0.7, 95% CI 0.6-1.0, p=0.03). Antihypertensive medication use at baseline was associated with a reduced incidence of dementia compared to no use (adjusted RR 0.7; 95% CI 0.6-1.0; P=0.03).