Key result
Cardiac troponin I cutoffs below the 99th percentile, such as the 90th percentile (HR 3.1; 95% CI 1.9-5.1), provided better prognostic discrimination for 5-year mortality in stabilized ACS patients.
Why the study?
Do cardiac troponin I cutoffs below the 99th percentile provide better prognostic discrimination for 5-year mortality in stabilized acute coronary syndrome patients compared to the 99th percentile cutoff?
Observational (n=1,957)
Do cardiac troponin I cutoffs below the 99th percentile provide better prognostic discrimination for 5-year mortality in stabilized acute coronary syndrome patients compared to the 99th percentile cutoff?
Effect estimate: HR 3.1 (95% CI 1.9-5.1)
Cardiac troponin I cutoffs below the 99th percentile (such as the 75th and 90th percentiles) provide better prognostic discrimination for 5-year mortality in stabilized ACS patients than the standard 99th percentile cutoff.
No takes yet. Share an insight, caveat, or question.
Lower troponin I thresholds may refine post-ACS risk stratification; leaves open whether to supplant the 99th percentile cutoff.
Eggers et al. (2008) conducted an observational in Coronary artery disease / Acute coronary syndrome (n=1,957). Cardiac troponin I (cTnI) cutoffs below the 99th percentile vs. 99th percentile cutoff was evaluated on 5-year mortality (HR 3.1, 95% CI 1.9-5.1). Cardiac troponin I cutoffs below the 99th percentile, such as the 90th percentile (HR 3.1; 95% CI 1.9-5.1), provided better prognostic discrimination for 5-year mortality in stabilized ACS patients.
Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context: