Key result
Modern cardiac troponin assays correlate poorly, yielding up to ~70% unique elevations per assay.
Why the study?
Do different modern cardiac troponin assays identify the same healthy individuals as being above the 99th percentile cutoff?
Population
2005 apparently healthy blood donors
Design
Cross-sectional
Authors
Loading...
Discordant troponin results above the 99th percentile across assays may complicate single-value interpretation; leaves open assay-specific thresholds or delta-based strategies.
Cross-Sectional (n=2,005)
Do different modern cardiac troponin assays identify the same healthy individuals as being above the 99th percentile cutoff?
There is poor concordance among different high-sensitivity cardiac troponin assays at the 99th percentile cutoff, suggesting that delta values should be emphasized over absolute cutoffs for diagnosing myocardial infarction.
Ungerer et al. (2016) conducted a cross-sectional in Healthy blood donors (n=2,005). Cardiac troponin assays (Abbott hs-cTnI, Beckman Coulter cTnI, Roche hs-cTnT) was evaluated on 99th percentile reference intervals and assay correlation. Three modern cardiac troponin assays demonstrated poor correlation (R2=0.01-0.18), with 50% to 70% of results above the 99th percentile cutoff being unique to individual assays.
Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context: