Key result
The 99th percentile upper reference limit of cardiac troponin remains the best-established, evidence-based criterion for diagnosing acute myocardial infarction.
Why the study?
Concerns exist regarding how the 99th percentile upper reference limit of cardiac troponin is determined and whether it should be derived from normal healthy individuals.
The 99th percentile upper reference limit of cardiac troponin remains the analytically and clinically evidence-based standard for diagnosing acute myocardial infarction.
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Supports continued guideline use of the 99th percentile for AMI diagnosis; leaves open assay-specific prospective validation.
Sandoval et al. (2020) conducted a review in Acute Myocardial Infarction. 99th percentile upper reference limit of cardiac troponin vs. Higher cutoff concentrations was evaluated. The 99th percentile upper reference limit of cardiac troponin remains the best-established, evidence-based criterion for diagnosing acute myocardial infarction.
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