What question did this study set out to answer?

Determine the relative contributions of cyclooxygenase-1 and cyclooxygenase-2 to the enhanced biosynthesis of prostacyclin, thromboxane A2, and isoprostanes in patients with atherosclerosis.

August 22, 2000Circulation

Cyclooxygenase-1 and -2–Dependent Prostacyclin Formation in Patients With Atherosclerosis

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Determine the relative contributions of cyclooxygenase-1 and cyclooxygenase-2 to the enhanced biosynthesis of prostacyclin, thromboxane A2, and isoprostanes in patients with atherosclerosis.
Studied 42 patients with atherosclerosis undergoing surgical revascularization, evaluating COX-1 and COX-2 mRNA and immunohistochemical localization in vascular tissue.
Randomized 24 aspirin-naive patients to either nimesulide or no treatment starting 24 hours preoperatively through 3 days postoperatively.
Assigned 18 patients already taking aspirin to either continue aspirin alone or take combined aspirin and nimesulide, measuring urinary metabolite levels of thromboxane A2, prostacyclin, and isoprostane.
Atherosclerosis patients exhibited higher urinary excretion than healthy controls for 11-dehydro-TXB2 (3211±533 vs 679±63 pg/mg creatinine, P<0.001) and 2,3-dinor-6-keto-PGF1alpha (594±156 vs 130±22 pg/mg creatinine, P<0.05).
Nimesulide reduced urinary 2,3-dinor-6-keto-PGF1alpha excretion by 46±5% preoperatively (from 378.3±103 to 167±37 pg/mg creatinine, P<0.01) and blunted postoperative increases, but exerted no significant effect on 11-dehydro-TXB2 (2678±694 to 2110±282 pg/mg creatinine).
Patients taking aspirin had lower baseline levels of both metabolites with no additional reduction from nimesulide, and neither intervention altered urinary 8-iso-PGF2alpha excretion.

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Implication

Randomized trial reveals that both COX-1 and COX-2 drive elevated prostacyclin biosynthesis in surgical atherosclerosis patients, suggesting distinct enzymatic roles in vascular eicosanoid pathways.

Cite This Study

Belton et al. (2000) studied this question.

synapsesocial.com/papers/6a175f9d3aabde875b12743a https://doi.org/10.1161/01.cir.102.8.840

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Implication

Randomized trial reveals that both COX-1 and COX-2 drive elevated prostacyclin biosynthesis in surgical atherosclerosis patients, suggesting distinct enzymatic roles in vascular eicosanoid pathways.

Cyclooxygenase-1 and -2–Dependent Prostacyclin Formation in Patients With Atherosclerosis

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Discussion

Implication

Cite This Study

Cyclooxygenase-1 and -2–Dependent Prostacyclin Formation in Patients With Atherosclerosis

Key Points

Discussion

Implication

Cite This Study

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