What question did this study set out to answer?

To review the global epidemiology, geographic variability, genetic determinants, and long-term progression risk associated with IgA nephropathy.

September 1, 2024Seminars in NephrologyOpen Access

IgA Nephropathy: Epidemiology and Disease Risk Across the World

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To review the global epidemiology, geographic variability, genetic determinants, and long-term progression risk associated with IgA nephropathy.
Synthesized findings from international kidney biopsy registries and population-based epidemiological cohorts.
Evaluated geographic and ancestral variations in genetic risk alleles across Eurasian populations.
Assessed long-term prognostic studies and multicenter validation data for the International IgA Nephropathy Prediction Tool.
Disease incidence displays a pronounced geographic gradient increasing from west to east and south to north across Eurasia, mirroring ancestral distributions of genetic risk alleles.
Long-term follow-up demonstrates an exceptionally high lifetime risk of progression to kidney failure, disproving historical perceptions of the disease as indolent.
The International IgA Nephropathy Prediction Tool successfully stratifies progression risk across multiethnic cohorts to guide targeted clinical trial interventions.

Authors

MGMalak GhaddarBC Cancer Agency MCMark CanneyUniversity of Ottawa SBSean J. BarbourProvincial Health Services Authority

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Implication

Epidemiological review reveals marked geographic variation and high kidney failure risk in IgA nephropathy, highlighting the need for improved global risk stratification.

Cite This Study

Ghaddar et al. (2024) studied this question.

synapsesocial.com/papers/6a176a2940149b897cb401b0 https://doi.org/10.1016/j.semnephrol.2025.151564

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Implication

Epidemiological review reveals marked geographic variation and high kidney failure risk in IgA nephropathy, highlighting the need for improved global risk stratification.

IgA Nephropathy: Epidemiology and Disease Risk Across the World

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Discussion

Implication

Cite This Study

IgA Nephropathy: Epidemiology and Disease Risk Across the World

Key Points

Discussion

Implication

Cite This Study

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