Key result
Early surgery for post-infarct ventricular septal rupture had an in-hospital mortality of 52.4%, compared to 7.56% for delayed surgery, with shorter time to surgery predicting unfavourable outcomes.
Why the study?
Does early surgery reduce in-hospital mortality compared to delayed surgery in patients with post-infarct ventricular septal rupture?
Population
3,238 patients undergoing surgery for post-infarct ventricular septal rupture, mean age 67.5 ± 8.8 years…
Comparison
Early surgery vs Delayed surgery
Design
Systematic_review
Follow-up
in-hospital
Authors
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Delayed surgery associated with lower mortality in post-infarct VSR; supports individualized timing but leaves optimal strategy open pending RCTs.
Systematic Review (n=3,238)
Does early surgery reduce in-hospital mortality compared to delayed surgery in patients with post-infarct ventricular septal rupture?
Absolute Event Rate: 52.4% vs 7.56%
Delayed surgery for post-infarct ventricular septal rupture is associated with lower in-hospital mortality compared to early surgery, though timing must be individualized based on the patient's hemodynamic stability.
Papalexopoulou et al. (2012) conducted a systematic review in post-infarct ventricular septal rupture (n=3,238). Early surgery vs. Delayed surgery was evaluated on in-hospital mortality. Early surgery for post-infarct ventricular septal rupture had an in-hospital mortality of 52.4%, compared to 7.56% for delayed surgery, with shorter time to surgery predicting unfavourable outcomes.
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