Key result
Diltiazem normalizes resting BP but fails to improve blunted LV filling during exercise in hypertensives.
Why the study?
Hypertension is associated with impaired LV diastolic function, but the impact of stress on LV filling in treated hypertensive individuals remains unclear.
Does diltiazem treatment improve stress-related left ventricular filling abnormalities in hypertensive patients with left ventricular hypertrophy?
Population
14 hypertensive patients and 14 age-sex matched normotensive controls
Comparison
Hypertensive patients vs normotensive controls at rest and post-exercise
Authors
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Diltiazem may not resolve exercise-induced diastolic dysfunction despite BP control; leaves open targeted therapies for stress LV filling in hypertensive LVH.
Cohort (n=28)
Single-blind
No
Does diltiazem treatment improve stress-related left ventricular filling abnormalities in hypertensive patients with left ventricular hypertrophy?
Absolute Event Rate: 21% vs 37%
p-value: p=<0.05
Antihypertensive treatment with diltiazem improves resting left ventricular filling and reduces left ventricular mass but fails to normalize stress-induced diastolic dysfunction in hypertensive patients.
K et al. (2022) conducted a cohort in Hypertension with left ventricular hypertrophy (n=28). Diltiazem vs. Normotensive controls was evaluated on Percentage change in early filling velocity (%E) with exercise (p=<0.05). Diltiazem treatment for 24 weeks normalized resting blood pressure but did not improve the blunted left ventricular filling response to exercise in hypertensive patients compared to controls.
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