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December 1, 1989Angiology

Atrial filling fractions were higher in hypertensives than in normals at rest (37 +/- 6% vs 24 +/- 7%, p < 0.05), and this difference increased during isometric stress (44 +/- 9% vs 30 +/- 11%).

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Why the study?

Does isometric stress accentuate left ventricular filling abnormalities in hypertensive young adults with mild to moderate left ventricular hypertrophy?

Population

16 subjects, comprising 7 hypertensive subjects with mild to moderate left ventricular hypertrophy and 9…

Comparison

Isometric stress vs Rest and matched healthy control males

Design

Case-control

Authors

EAEdward G. AbinaderDSDawod SharifMSMicael Sagiv

Discussion

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Overview

Isometric stress may unmask atrial-dependent LV filling in mild hypertension; hypothesis-generating for early detection, needs prospective validation.

Structured PICO

Does isometric stress accentuate left ventricular filling abnormalities in hypertensive young adults with mild to moderate left ventricular hypertrophy?

P
Population
16 subjects, comprising 7 hypertensive subjects with mild to moderate left ventricular hypertrophy (aged 42 +/- 7 years) and 9 matched healthy control males.
I
Intervention
Isometric stress
C
Comparator
Rest (within-subject) and matched healthy control males (between-subject)
O
Outcome
Left ventricular filling parameters measured by Doppler interrogation (peak early diastolic (E) velocity, atrial (A) velocity, E/A peak velocity ratio, and atrial filling fractions)surrogate

Isometric stress accentuates the reliance of left ventricular filling on atrial contribution, which may be useful for detecting early ventricular filling abnormalities in patients with mild hypertension.

Cite This Study

Abinader et al. (1989) studied this question.

synapsesocial.com/papers/6a6f2efbf44fa9f079dc9842https://doi.org/10.1177/000331978904001206
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1The effects of isometric stress on left ventricular filling in athletes with isometric or isotonic training compared to hypertensive and normal controls1996 · 20 citations
  2. 2Effects of Reduced Preload on Diastolic Filling in Essential Hypertensive Patients With Increased Left Ventricular Mass1997 · 8 citations
  3. 3Influence of Mild to Moderate Obesity on Left Ventricular Stress Filling Pattern in Hypertension.1998 · 8 citations
  4. 4Persistence of Stress Related Left Ventricular Filling Abnormality in Treated Hypertensive Patients2022
  5. 5Myocardial hypertrophy and left ventricular diastolic function in hypertensive patients: an echo Doppler evaluation1989 · 28 citations