Key result
Pretreatment with Methyl-GBB attenuated infarct size by 45% and improved 24-hour survival of rats by 20-30% following acute ischaemia-reperfusion.
Why the study?
Does Methyl-GBB reduce infarct size and improve survival in rat models of acute ischaemia-reperfusion injury?
Population
Rat models of acute ischaemia-reperfusion injury (isolated hearts and in vivo)
Comparison
Methyl-GBB (4-[ethylammonio]butanoate) 5 or 20… vs Untreated control
Design
Preclinical
Follow-up
24 h
Authors
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Hypothesis-generating for metabolic cardioprotection; human trials required before clinical consideration.
Does Methyl-GBB reduce infarct size and improve survival in rat models of acute ischaemia-reperfusion injury?
Effect estimate: 45-48% reduction
Inhibition of L-carnitine biosynthesis and transport by Methyl-GBB protects against myocardial infarction by reducing fatty acid oxidation and facilitating glucose metabolism in rat models.
Liepinsh et al. (2014) studied Acute ischaemia-reperfusion injury / Myocardial infarction. Methyl-GBB was evaluated on Infarct size (45-48% reduction). Pretreatment with Methyl-GBB attenuated infarct size by 45% and improved 24-hour survival of rats by 20-30% following acute ischaemia-reperfusion.
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