Key result
Comparing the platelet transcriptome and proteome reveals an under-representation of nuclear proteins.
Why the study?
Technical, normalization, and database-dependent challenges must be addressed to combine human platelet transcriptomes and proteomes into a complete reference profile.
A complete reference transcriptome and proteome for human platelets can help elucidate intra- and inter-subject differences in health and disease, and aid in genetic diagnostics.
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Highlights gaps in platelet proteome coverage; leaves open diagnostic utility in health and disease.
Huang et al. (2023) conducted a review in Platelet biology. Comparing the classified platelet transcriptome (17.6k transcripts) with the identified platelet proteome (5.2k proteins) reveals an under-representation of nuclear and other specific proteins.
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