Key result
Deep RNA sequencing of human platelets revealed a highly complex transcriptome containing approximately 9,500 protein-coding transcripts, numerous microRNAs, and thousands of novel un-annotated transcripts.
Population
Leukocyte-depleted platelets from 4 healthy individuals
Comparison
Deep RNA sequencing (RNA-seq) vs Microarray
Design
Preclinical
Authors
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May inform platelet RNA studies in thrombosis; leaves open functional roles of novel transcripts in cardiovascular disease.
Observational (n=4)
No
Deep RNA sequencing of human platelets reveals a highly complex transcriptome including thousands of novel non-coding and intronic transcripts, expanding upon previous microarray estimates.
Bray et al. (2013) conducted an observational in Healthy (platelet transcriptome) (n=4). RNA sequencing was evaluated on Platelet transcriptome profile. Deep RNA sequencing of human platelets revealed a highly complex transcriptome containing approximately 9,500 protein-coding transcripts, numerous microRNAs, and thousands of novel un-annotated transcripts.
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