Key result
Explanted decellularized heart valves showed substantial in vivo recellularization, with histologic scores of 76% in nonendocarditis vs 48% in endocarditis specimens (p=0.0004).
Why the study?
Unlike animal data, there have only been sporadic histologic reports on the in vivo recellularization of allogenic decellularized heart valves in humans.
Does implantation of decellularized heart valves result in in vivo recellularization in humans?
Population
11 human specimens from 364 implanted decellularized heart valves
Design
Observational study with independent pathologist evaluation
Authors
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Supports decellularized valve development as living implants; leaves open durability, infection resistance, and need for randomized trials.
Observational (n=11)
Does implantation of decellularized heart valves result in in vivo recellularization in humans?
Absolute Event Rate: 76% vs 48%
p-value: p=0.0004
Decellularized heart valves demonstrate substantial spontaneous in vivo recellularization with noninflammatory cells over multiple months in humans.
Sarikouch et al. (2019) conducted an observational in Decellularized heart valve implantation (n=11). Decellularized heart valves vs. Endocarditis specimens was evaluated on Relative histologic score (p=0.0004). Explanted decellularized heart valves showed substantial in vivo recellularization, with histologic scores of 76% in nonendocarditis vs 48% in endocarditis specimens (p=0.0004).
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