Key result
Decellularized pulmonary homografts showed superior 10-year freedom from explantation versus cryopreserved homografts (96.7% vs 84.4%, P=0.029) and bovine jugular vein conduits (82.7%, P=0.012).
Why the study?
Decellularized pulmonary homografts showed excellent results for pulmonary valve replacement, but controlled multicentre studies were lacking.
Does the use of decellularized pulmonary homografts improve freedom from explantation and structural valve degeneration compared to bovine jugular vein conduits and cryopreserved homografts in patients undergoing pulmonary valve replacement?
Population
121 prospectively enrolled patients plus 114 registry patients undergoing pulmonary valve replacement
Comparison
Decellularized pulmonary homografts vs bovine jugular vein conduits and cryopreserved homografts
Design
Prospective European multicentre trial with matched comparison and registry cohort
Follow-up
Mean 2.2 ± 0.6 years for trial cohort, 5.1 ± 3.0 years for registry
Authors
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Decellularized homografts associated with superior durability after pulmonary valve replacement; hypothesis-generating pending randomized confirmation.
Cohort (n=705)
Yes
Does the use of decellularized pulmonary homografts improve freedom from explantation and structural valve degeneration compared to bovine jugular vein conduits and cryopreserved homografts in patients undergoing pulmonary valve replacement?
Decellularized pulmonary homografts for pulmonary valve replacement demonstrate excellent safety and superior freedom from explantation at 10 years compared to bovine jugular vein conduits and cryopreserved homografts.
Boethig et al. (2019) conducted a cohort in pulmonary valve replacement (n=705). Decellularized pulmonary homografts (DPH) vs. Bovine jugular vein (BJV) conduits and cryopreserved homografts (CH) was evaluated on mean peak gradient and regurgitation. Decellularized pulmonary homografts showed superior 10-year freedom from explantation versus cryopreserved homografts (96.7% vs 84.4%, P=0.029) and bovine jugular vein conduits (82.7%, P=0.012).
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