Key result
In patients <20 years, pulmonary homografts had higher 10-year freedom from reintervention (80%) compared to bovine jugular vein conduits (37%, P<0.001) and aortic homografts (47%).
Why the study?
The study was conducted to compare the performance of homografts and bovine jugular vein conduits in the pulmonary position.
Do pulmonary homografts reduce reintervention, structural valve degeneration, and infective endocarditis compared to bovine jugular vein conduits in patients <20 years of age undergoing pulmonary valve replacement?
Population
Patients with congenital heart disease up to age 20 years receiving 674 conduits at 3 centers in Australia
Comparison
Pulmonary homografts vs bovine jugular vein conduits vs aortic homografts
Design
Multicenter propensity score-matched cohort study
Follow-up
Median 6.4 years
Authors
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Pulmonary homografts may offer better durability than BJV conduits for larger sizes in patients <20 years; leaves open need for prospective trials before practice change.
Cohort (n=674)
Yes
Do pulmonary homografts reduce reintervention, structural valve degeneration, and infective endocarditis compared to bovine jugular vein conduits in patients <20 years of age undergoing pulmonary valve replacement?
Absolute Event Rate: 80% vs 37%
p-value: p=<.001
In patients under 20 years of age requiring pulmonary valve replacement with conduits >15 mm, pulmonary homografts significantly outperform bovine jugular vein conduits and aortic homografts in freedom from reintervention and structural valve degeneration.
Marathe et al. (2021) conducted a cohort in Congenital heart disease (n=674). Pulmonary homografts vs. Bovine jugular vein conduits and aortic homografts was evaluated on Freedom from reintervention at 10 years (p=<.001). In patients <20 years, pulmonary homografts had higher 10-year freedom from reintervention (80%) compared to bovine jugular vein conduits (37%, P<0.001) and aortic homografts (47%).
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