Key result
Fresh decellularized pulmonary homografts achieved 100% 5-year freedom from explantation versus 86% for bovine jugular veins and 88% for cryopreserved homografts in pulmonary valve replacement.
Why the study?
Does fresh decellularized pulmonary homograft implantation improve freedom from explantation and hemodynamics compared with bovine jugular vein and cryopreserved homografts in children and young adults requiring pulmonary valve replacement?
Population
114 children and young adults requiring pulmonary valve replacement.
Comparison
Fresh decellularized pulmonary homografts… vs Glutaraldehyde-fixed bovine jugular vein and…
Design
Cohort
Follow-up
up to 5 years
Authors
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May support fresh decellularized pulmonary homografts in pulmonary valve replacement; hypothesis-generating and requires randomized confirmation.
Cohort (n=114)
Does fresh decellularized pulmonary homograft implantation improve freedom from explantation and hemodynamics compared with bovine jugular vein and cryopreserved homografts in children and young adults requiring pulmonary valve replacement?
Absolute Event Rate: 100% vs 86%
Fresh decellularized pulmonary homografts for pulmonary valve replacement in young patients demonstrate excellent 5-year freedom from explantation and favorable hemodynamics compared to conventional grafts.
Cebotari et al. (2011) conducted a cohort in Pulmonary valve replacement (n=114). Fresh decellularized pulmonary homografts (DPH) vs. Glutaraldehyde-fixed bovine jugular vein (BJV) and cryopreserved homografts (CH) was evaluated on Five-year freedom from explantation. Fresh decellularized pulmonary homografts achieved 100% 5-year freedom from explantation versus 86% for bovine jugular veins and 88% for cryopreserved homografts in pulmonary valve replacement.
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