Key result
Propranolol infusion reduced cardiac output from 10.6 to 4.1 L/min, primarily at the expense of blood flow to the fast peripheral circuit, and reduced its blood volume by more than half.
Why the study?
Does propranolol infusion alter blood volume and flow distribution in healthy adult men?
Population
4 healthy adult men
Comparison
Propranolol infusion vs Baseline (no propranolol)
Design
Other
Authors
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Does not support practice change from healthy volunteer data; leaves open validation of peripheral flow effects and modeling in patients.
Does propranolol infusion alter blood volume and flow distribution in healthy adult men?
Absolute Event Rate: 4.1% vs 10.6%
A recirculatory multicompartmental indocyanine green model can effectively characterize the reduction in cardiac output and peripheral blood volume caused by propranolol infusion.
Claus U. Niemann (2000) studied Healthy (n=4). Propranolol infusion vs. Baseline (no propranolol) was evaluated on Cardiac output. Propranolol infusion reduced cardiac output from 10.6 to 4.1 L/min, primarily at the expense of blood flow to the fast peripheral circuit, and reduced its blood volume by more than half.
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