Key result
Relative dispersion of transit times increased linearly with cardiac output, with antipyrine showing a diffusional equilibration time in the extravascular space of approximately 10 min.
Population
Awake dogs
Comparison
Phenylephrine or isoproterenol infusion with… vs Control conditions
Design
Preclinical
Authors
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Offers in vivo model for solute distribution kinetics; extends theoretical predictions but hypothesis-generating for clinical translation.
An in vivo model using relative dispersion of transit times effectively measures whole body distribution kinetics of solutes, explaining flow and capillary permeability effects without assuming well-mixed compartments.
Weiß et al. (2006) studied this question. Phenylephrine or isoproterenol infusion vs. Control conditions was evaluated on Relative dispersion of transit times across the systemic and pulmonary circulation. Relative dispersion of transit times increased linearly with cardiac output, with antipyrine showing a diffusional equilibration time in the extravascular space of approximately 10 min.
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