Key result
Numerical simulations showed that mixing time is determined by cardiac output and transit time dispersion, with mixing times >3 min leading to overestimation of blood volume.
Why the study?
What are the determinants of circulatory mixing time in a simulation model?
Population
Circulatory model applied to the intravascular marker indocyanine green (ICG)
Design
Other
Authors
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May overestimate blood volume by indicator dilution in low-output states; leaves open in vivo validation.
What are the determinants of circulatory mixing time in a simulation model?
In states of low cardiac output or high transit time dispersion, slow circulatory mixing can lead to significant overestimation of blood volume when using indicator dilution methods.
Michael Weiß (2009) studied this question. Numerical simulations using a circulatory model was evaluated on Mixing time (time required for achieving 95% homogeneity). Numerical simulations showed that mixing time is determined by cardiac output and transit time dispersion, with mixing times >3 min leading to overestimation of blood volume.
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