Key result
A recirculatory compartmental model of indocyanine green disposition in dogs determined that central blood volume averaged 23.4 ml/kg and total blood volume averaged 78.9 ml/kg.
Population
5 dogs deeply anesthetized with halothane
Design
Preclinical
Follow-up
20 minutes
Authors
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May inform canine pharmacokinetic modeling; leaves open translation to human drug distribution studies.
A new fully identifiable recirculatory compartmental model successfully describes ICG disposition and intravascular mixing, providing a method to determine the circulation's contribution to drug distribution.
Henthorn et al. (1992) studied this question. Indocyanine green (ICG) injection was evaluated on ICG disposition and circulatory mixing parameters. A recirculatory compartmental model of indocyanine green disposition in dogs determined that central blood volume averaged 23.4 ml/kg and total blood volume averaged 78.9 ml/kg.
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