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August 1, 1966Circulation ResearchOpen Access

Plasma Indicator Dispersion in Arteries of the Human Leg

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Population

5 normal men

Design

Other

Authors

JBJames B. BassingthwaighteElectrophysiology

Discussion

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Implication

Arterial geometry, not flow, drives indicator dispersion in leg arteries; hypothesis-generating for vascular models but should not yet change clinical transit time use.

Structured PICO

P
Population
5 normal men
I
Intervention
Injection of indocyanine green into the superior vena cava or thoracic aorta
O
Outcome
Transfer functions (distribution of transit times) for the arterial segment between femoral and dorsalis pedis arteriessurrogate

The rate of spatial longitudinal spreading of an indicator with distance traveled in human leg arteries is primarily a function of arterial geometry rather than flow rate.

Cite This Study

James B. Bassingthwaighte (1966) studied this question.

synapsesocial.com/papers/6a82aa70fdcaa17bff6d08f3https://doi.org/10.1161/01.res.19.2.332
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Also Consider

Synapse has enriched 2 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Applications of the Lagged Normal Density Curve as a Model for Arterial Dilution Curves1966 · 157 citations
  2. 2Indicator-Dilution Studies with "Diffusible" Indicators1962 · 67 citations