Key result
Diffusible indicator dilution estimates pulmonary capillary blood volume and transit time at ~48% of lobar totals.
Why the study?
The study aimed to examine the use of rapidly diffusing flow-limited indicators to estimate pulmonary capillary blood volume and capillary transit time distribution.
Population
Isolated dog lung lobes
Comparison
Flow-limited diffusible indicators with varying perfusate albumin concentrations vs vascular reference indicator
Design
Preclinical experimental study with bolus injections and least-squares optimization
Authors
Loading...
Hypothesis-generating for pulmonary capillary volume estimation; in vivo validation required before research or clinical use.
This study provides a theoretical framework and experimental validation using isolated dog lungs for estimating pulmonary capillary blood volume and transit time using flow-limited diffusible indicators.
Audi et al. (1994) studied this question. Flow-limited diffusible indicators ([14C]-diazepam) vs. Vascular reference indicator was evaluated on Estimated capillary volume and mean transit time as a percentage of total lobar volume and mean transit time. Using flow-limited diffusible indicators in isolated dog lung lobes, the estimated capillary volume and mean transit time were approximately 48% of the total lobar volume and mean transit time.
Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context: