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May 1, 1970Circulation ResearchOpen Access

Frequency Function of Transit Times through Dog Pulmonary Circulation

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Population

Dogs (two preparations: closed chest with recirculation, open chest with only myocardial recirculation)

Comparison

Deconvolution of a pair of simultaneous tracer… vs Monoexponential extrapolation of the same tracer…

Design

Preclinical

Authors

AMAttilio MaseriGeneral CardiologyPCPaolo CaldiniNewton Wellesley HospitalSPSolbert PermuttUniversity of Pisa

Discussion

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Implication

May refine transit time estimates in animal models with early recirculation; leaves open translation to clinical cardiovascular research.

Structured PICO

P
Population
Dogs (two preparations: closed chest with recirculation, open chest with only myocardial recirculation)
I
Intervention
Deconvolution of a pair of simultaneous tracer dilution curves (pulmonary artery to aorta and left atrium to aorta)
C
Comparator
Monoexponential extrapolation of the same tracer concentration curves to eliminate recirculation
O
Outcome
Frequency function of pulmonary vascular transit timessurrogate

Deconvolution of simultaneous tracer dilution curves provides a more accurate estimate of pulmonary vascular transit times than monoexponential extrapolation when early recirculation is present.

Cite This Study

Maseri et al. (1970) studied this question.

synapsesocial.com/papers/6a82aa70fdcaa17bff6d08f2https://doi.org/10.1161/01.res.26.5.527

Topics

Sermorelin
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Also Consider

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  1. 1A Transfer Function Analysis of Coronary and Renal Circulation Calculated from Upstream and Downstream Indicator-Dilution Curves1966 · 49 citations
  2. 2THE PULMONARY BLOOD VOLUME IN MAN*1961 · 146 citations
  3. 3Pulmonary Vascular Volume, Resistance, and Compliance in Man1960 · 140 citations
  4. 4Plasma Indicator Dispersion in Arteries of the Human Leg1966 · 82 citations
  5. 5Applications of the Lagged Normal Density Curve as a Model for Arterial Dilution Curves1966 · 157 citations