Key result
Obstructive sleep apnea may contribute to the cardiovascular consequences of obesity, including hypertension, atherosclerosis, insulin resistance, and atrial fibrillation.
Identifying OSA-dependent and independent pathways in obesity-related cardiovascular pathophysiology may offer new clinical and therapeutic targets.
OSA evaluation may inform obesity-related CV risk; leaves open whether targeting OSA improves outcomes.
Obesity and obstructive sleep apnea (OSA) often coexist. OSA has been linked to cardiovascular disease. Thus, OSA may contribute to the cardiovascular consequences of obesity. In this review, we explore clinical and pathophysiological interactions between obesity, cardiovascular disease and OSA. We discuss the mechanisms whereby OSA may contribute to hypertension, atherosclerosis, insulin resistance and atrial fibrillation associated with obesity, and emphasize the potential implications for understanding why only a subgroup of obese patients develop cardiovascular disease. Identification of the OSA-dependent and OSA-independent pathways in the cardiovascular pathophysiology of obesity may hold clinical and therapeutic promise.
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Wołk et al. (2005) conducted a review in Obesity-related cardiovascular disease and obstructive sleep apnea. Obstructive sleep apnea may contribute to the cardiovascular consequences of obesity, including hypertension, atherosclerosis, insulin resistance, and atrial fibrillation.
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