Key result
One-month DAPT then aspirin after PF-DCS improves composite outcomes in stable CAD but not ACS.
Why the study?
The impact of 1-month DAPT followed by aspirin monotherapy according to clinical presentation had not been elucidated.
Does 1-month DAPT followed by aspirin monotherapy improve composite ischaemic and bleeding outcomes compared to 6-12-month DAPT in patients undergoing PCI for non-complex lesions according to clinical presentation?
RCT
Does 1-month DAPT followed by aspirin monotherapy improve composite ischaemic and bleeding outcomes compared to 6-12-month DAPT in patients undergoing PCI for non-complex lesions according to clinical presentation?
p-value: p==0.276
One-month DAPT followed by aspirin monotherapy after PF-DCS implantation may be beneficial for patients with stable CAD undergoing PCI for non-complex lesions, but not for those with ACS.
BACKGROUND: The impact of 1-month dual antiplatelet therapy (DAPT) followed by aspirin monotherapy according to clinical presentation has not been elucidated. AIMS: This study aimed to compare the impact of 1-month DAPT followed by aspirin monotherapy after polymer-free drug-coated stent (PF-DCS) implantation (1-month DAPT after PF-DCS) vs 6-12-month DAPT followed by aspirin monotherapy after biodegradable polymer drug-eluting stent (BP-DES) implantation (6-12-month DAPT after BP-DES) according to clinical presentation. METHODS: This is a post hoc analysis of the One-Month DAPT trial. The primary outcome was the composite of major adverse cardiac and cerebrovascular events (MACCE; a composite of cardiac death, non-fatal myocardial infarction, target vessel revascularisation, and stroke) and major bleeding. CONCLUSIONS: In patients undergoing drug-eluting stent implantation for non-complex lesions, the benefits of 1-month DAPT followed by aspirin monotherapy for a composite of ischaemic and bleeding outcomes were found in patients with stable CAD, but not in those with ACS. CLINICALTRIALS: gov: NCT02513810.
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Lee et al. (2022) conducted an RCT in percutaneous coronary intervention. 1-month DAPT followed by aspirin monotherapy after PF-DCS implantation vs. 6-12-month DAPT followed by aspirin monotherapy after BP-DES implantation was evaluated on composite of major adverse cardiac and cerebrovascular events (MACCE; a composite of cardiac death, non-fatal myocardial infarction, target vessel revascularisation, and stroke) and major bleeding (p==0.276). One-month DAPT followed by aspirin monotherapy after PF-DCS implantation improved composite ischaemic and bleeding outcomes in patients with stable CAD, but not in those with ACS.
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