Key result
One-month DAPT matches longer regimens for major bleeding and stent thrombosis risk.
Why the study?
The safety of 1-month dual antiplatelet therapy followed by aspirin or a P2Y12 receptor inhibitor after PCI with drug-eluting stents compared to longer DAPT durations was uncertain.
Does 1-month DAPT followed by single antiplatelet therapy improve safety and efficacy in patients undergoing PCI with DES compared to >1-month DAPT?
Meta-Analysis (n=26,431)
Does 1-month DAPT followed by single antiplatelet therapy improve safety and efficacy in patients undergoing PCI with DES compared to >1-month DAPT?
Odds Ratio: 0.74 (95% CI 0.51–1.07)
p-value: p=0.11
A 1-month DAPT strategy followed by single antiplatelet therapy is non-inferior to longer DAPT for stent thrombosis and major bleeding, and may reduce MACE in patients undergoing PCI with DES.
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Supports 1-month DAPT post-DES PCI; extends Level 1 evidence for de-escalation without excess thrombosis.
Bajraktari et al. (2022) conducted a meta-analysis in PCI with drug-eluting stents (n=26,431). 1-month DAPT followed by aspirin or a P2Y12 receptor inhibitor vs. >1-month DAPT was evaluated on major bleeding (OR 0.74, 95% CI 0.51-1.07, p=0.11). 1-month DAPT followed by aspirin or a P2Y12 inhibitor was non-inferior to >1-month DAPT for major bleeding (OR 0.74; 95% CI 0.51-1.07) and stent thrombosis (OR 1.10; 95% CI 0.82-1.47).
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