Observational study reveals hypohydration elevates acute kidney injury biomarkers after an ultramarathon, suggesting maintaining proper hydration mitigates post-race renal stress.
Urinary concentrations of several acute kidney injury (AKI) biomarkers increased after completing the 2023 Western States Endurance Run; however, there were no changes in renal blood flow in a subset of runners. When normalized to creatinine, several AKI biomarkers, including IGFBP7·TIMP2 (an FDA-approved biomarker of AKI), remained elevated. Notably, finishing the race euhydrated appeared to have a protective effect, mitigating increases in IGFBP7·TIMP2.
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Linder et al. (2025) studied this question.
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