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This research investigates the severe cutaneous reactions associated with captopril and explores the biochemical effects of phosphine.

April 13, 1985BMJOpen Access

Severe cutaneous reactions to captopril.

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Randomized trial examines severe reactions to captopril and phosphine's role in cutaneous toxicity, suggesting caution in usage.

This research investigates the severe cutaneous reactions associated with captopril and explores the biochemical effects of phosphine.
Examined the biochemical interaction of phosphine with cytochrome oxidase in various species.
Investigated the incidence of severe cutaneous reactions in patients using captopril.
Phosphine was found to non-competitively inhibit cytochrome oxidase, affecting mitochondrial function.
Severe cutaneous reactions were observed in patients using captopril with varying frequency.

Goodfield et al. (1985) studied this question.

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