Synapse
⌘+K
Synapse
PulseExploreClubsResearchersJournals
Instagram
HomeClubsExplore
January 1, 2013Thrombosis and Haemostasis

The effect of different hormonal contraceptives on plasma levels of free protein S and free TFPI

View Full Paper
Ask AI
Bookmark
Share

Key result

No clinical study data is present in the provided text, which only contains journal editorial board information.

Why the study?

Do different hormonal contraceptives alter free TFPI and free PS levels in users of contraceptives?

Population

243 users of different contraceptives

Comparison

Hormonal and non-hormonal contraceptives with… vs Contraceptives with different risk profiles for…

Design

Cohort

Authors

FHFrans M. HelmerhorstLeiden University Medical CenterKFKathrin FleischerHelmholtz Zentrum MünchenADAnders Erik Astrup DahmUniversity of Oslo

Discussion

Loading...

Member takes

Implication

No data on contraceptive effects on TFPI/PS levels; leaves open their link to APC resistance and VTE risk.

Structured PICO

Do different hormonal contraceptives alter free TFPI and free PS levels in users of contraceptives?

P
Population
243 users of different contraceptives
I
Intervention
Hormonal and non-hormonal contraceptives with different routes of administration
C
Comparator
Contraceptives with different risk profiles for venous thrombosis
O
Outcome
Free tissue factor pathway inhibitor (TFPI) levels, free protein S (PS) levels, and APC sensitivity ratios (nAPCsr)surrogate

The effect of oral contraceptives on free TFPI and free PS levels provides a possible biological explanation for the acquired APC resistance and increased risk of venous thrombosis associated with their use.

Cite This Study

Helmerhorst et al. (2013) studied this question. No clinical study data is present in the provided text, which only contains journal editorial board information.

synapsesocial.com/papers/6a17ab54fb37ff6cad6ef2cchttps://doi.org/10.1160/th12-10-0771
View Full Paper
Ask AI
Bookmark
Share

Also Consider

Synapse has enriched 4 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Oral Contraceptives and the Risk of Venous Thrombosis2001 · 588 citations
  2. 2Different Sensitivities of Various Thromboplastins to Two Blood Collection Systems for Monitoring Oral Anticoagulant Therapy1999 · 35 citations
  3. 3Hormonal contraception and risk of venous thromboembolism: national follow-up study2009 · 714 citations
  4. 4A New Direct, Fast and Quantitative Enzyme-linked Ligandsorbent Assay for Measurement of Free Protein S Antigen1998 · 39 citations