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January 1, 2005Thrombosis and Haemostasis

Effect of oral contraceptives on the anticoagulant activity of protein S in plasma

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Why the study?

Does oral contraceptive use alter the anticoagulant activity of protein S in plasma compared to non-users and men?

Population

Men, women not using oral contraceptives, and women using second or third generation oral contraceptives

Comparison

Second or third generation oral contraceptives vs Men and women not using oral contraceptives

Design

Cross-sectional

Authors

RKRory R. KoenenMaastricht UniversitySTStella ThomassenMaastricht School of ManagementGTGuido TansMaastricht University

Discussion

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Implication

OC use may lower protein S anticoagulant activity and thrombosis risk; leaves open causal mechanisms and assay utility for risk stratification.

Structured PICO

Does oral contraceptive use alter the anticoagulant activity of protein S in plasma compared to non-users and men?

P
Population
Men, women not using oral contraceptives, and women using second or third generation oral contraceptives
I
Intervention
Second or third generation oral contraceptives
C
Comparator
Men and women not using oral contraceptives
O
Outcome
Anticoagulant parameters dependent on protein S function (APC-independent anticoagulant activity of protein S [pSR], APC resistance [APCsr], plasma levels of total and free protein S and prothrombin)surrogate

Oral contraceptive use alters the expression of protein S activity, which may contribute to the increased thrombotic risk observed in users.

Cite This Study

Koenen et al. (2005) studied this question.

synapsesocial.com/papers/6a913e60ae2c4ed52ef1287chttps://doi.org/10.1160/th04-11-0762
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Oral contraceptives and gender affect protein S status1987 · 143 citations
  2. 2Oral contraceptives and gender affect protein S status1987 · 9 citations
  3. 3The effect of different hormonal contraceptives on plasma levels of free protein S and free TFPI2013 · 27 citations
  4. 4Evaluation of Coagulometric Assays in the Assessment of Protein C Anticoagulant Activity; Variable Sensitivity of Commercial APTT Reagents to the Cofactor Effect of Protein S1989 · 14 citations
  5. 5Activated Protein C Sensitivity, Protein C, Protein S and Coagulation in Normal Pregnancy1998 · 386 citations