Key result
NT-proBNP levels were significantly higher in patients with stage 2 hypertension compared to stage 1 hypertension (p<0.001), and in those with hypertension >6 years versus <6 years (p=0.010).
Why the study?
NT-proBNP is independently associated with an increased risk of hypertension, but the differences and correlation of its serum levels between stage 1 and stage 2 hypertension needed evaluation.
Are NT-proBNP levels associated with the severity and duration of hypertension?
Cross-Sectional (n=72)
No
Are NT-proBNP levels associated with the severity and duration of hypertension?
p-value: p=<0.001
NT-proBNP levels are significantly elevated in patients with stage 2 hypertension and longer disease duration compared to stage 1 and shorter duration, suggesting a link between hypertension severity/duration and myocardial stress.
NT-proBNP may mark myocardial strain in advanced hypertension; hypothesis-generating and requires prospective validation before clinical use.
The increased levels of NT-proBNP in the blood occur when heart function, especially the left ventricular muscle chambers of the heart increases. Therefore, NT-proBNP is used as a biomarker to detect heart failure.The level of N Terminal – Pro Brain Natriuetic Peptide was independently associated with an increased risk of hypertension. This study aimed to determine the difference of NT-proBNP serum levels and the correlation between the levels of NT-proBNP in patients with stage 1 and stage 2 hypertension. This research was conducted at RSUP dr. Wahidin Sudirohusodo in August - September 2018. The study used a cross-sectional design with the total of 72 hypertensive patients, who had met the inclusive criteria. NT-proBNP levels were measured using the ELISA (Enzyme Linked Immunosorbent Assay) method. The collected data was processed using Mann Whitney Different Test and Spearman's rho Correlation Test. The study results indicated that the level of NT-proBNP in the hypertensive patients with stage 2 was higher and significantly different (p = <0.001) compared to stage 1 hypertensive patients. NT-proBNP levels were higher in the hypertensive group of >6 years than in the hypertensive group <6 years. There were significant differences between the two groups statistically (p=0.010). It can be Conclude that there is a significant difference in the levels of NT-proBNP with a degree of hypertension where NT-proBNP levels were higher in patients with stage 2 hypertension compared to stage 1 hypertension, although there was not statistically significant correlation between levels of NT-proBNP with Hypertension degree. Further research was needed to determine the relationship of NT-proBNP levels with the degree of hypertension, which can confirm the diagnosis, especially in patients with hypertension. Also, it is suggested to consider the accuracy of the data length of a patient suffering from undiagnosed hypertension.
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Supriati Wila Djami (2019) conducted a cross-sectional in Stage 1 and stage 2 hypertension (n=72). Stage 2 hypertension vs. Stage 1 hypertension was evaluated on NT-proBNP serum levels (p=<0.001). NT-proBNP levels were significantly higher in patients with stage 2 hypertension compared to stage 1 hypertension (p<0.001), and in those with hypertension >6 years versus <6 years (p=0.010).
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