Key result
Assays of several viral RNA genomes revealed similarly placed RNase P cleavage sites in their IRES domains, indicating that a tRNA-like domain may be a general structural feature of IRESs.
A tRNA-like domain may be a general structural feature of viral IRESs, potentially recognized by ribosomal tRNA-binding sites during initiation.
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May suggest conserved viral IRES features; leaves open any therapeutic relevance in human infections.
Lyons et al. (2003) studied Viral RNA IRES structure. RNase P cleavage assay was evaluated on Presence of RNase P cleavage sites in IRES domains. Assays of several viral RNA genomes revealed similarly placed RNase P cleavage sites in their IRES domains, indicating that a tRNA-like domain may be a general structural feature of IRESs.
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