Key result
MMP-9 levels correlated significantly with aortic (r=0.45; P=0.001) and brachial pulse wave velocity (r=0.22; P=0.002), suggesting elastases are involved in arterial stiffening and ISH development.
Why the study?
Are MMP-9, MMP-2, and serum elastase activity associated with arterial stiffness in patients with isolated systolic hypertension and healthy individuals?
Population
116 subjects with isolated systolic hypertension, 114 matched controls, and 447 individuals free from…
Design
Cross-sectional
Authors
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Supports MMP-9 as stiffness biomarker in ISH; hypothesis-generating for elastase targeting, needs prospective validation.
Observational (n=677)
Are MMP-9, MMP-2, and serum elastase activity associated with arterial stiffness in patients with isolated systolic hypertension and healthy individuals?
Effect estimate: r=0.45
p-value: p=0.001
MMP-9 and serum elastase activity are associated with aortic stiffness in both isolated systolic hypertension and healthy individuals, suggesting a role in arterial stiffening.
Yasmin et al. (2004) conducted an observational in Isolated systolic hypertension and arterial stiffness (n=677). MMP-9, MMP-2, and serum elastase activity vs. Healthy controls was evaluated on Correlation of MMP-9 levels with aortic pulse wave velocity (r=0.45, p=0.001). MMP-9 levels correlated significantly with aortic (r=0.45; P=0.001) and brachial pulse wave velocity (r=0.22; P=0.002), suggesting elastases are involved in arterial stiffening and ISH development.
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