Key result
MMP-9 levels correlated significantly with aortic (r=0.45; P=0.001) and brachial pulse wave velocity (r=0.22; P=0.002), suggesting elastases are involved in arterial stiffening and ISH development.
Why the study?
Are MMP-9, MMP-2, and serum elastase activity associated with arterial stiffness in patients with isolated systolic hypertension and healthy individuals?
Observational (n=677)
Are MMP-9, MMP-2, and serum elastase activity associated with arterial stiffness in patients with isolated systolic hypertension and healthy individuals?
Effect estimate: r=0.45
p-value: p=0.001
MMP-9 and serum elastase activity are associated with aortic stiffness in both isolated systolic hypertension and healthy individuals, suggesting a role in arterial stiffening.
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Supports MMP-9 as stiffness biomarker in ISH; hypothesis-generating for elastase targeting, needs prospective validation.
Yasmin et al. (2004) conducted an observational in Isolated systolic hypertension and arterial stiffness (n=677). MMP-9, MMP-2, and serum elastase activity vs. Healthy controls was evaluated on Correlation of MMP-9 levels with aortic pulse wave velocity (r=0.45, p=0.001). MMP-9 levels correlated significantly with aortic (r=0.45; P=0.001) and brachial pulse wave velocity (r=0.22; P=0.002), suggesting elastases are involved in arterial stiffening and ISH development.
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