Why the study?
Are MMP-9 gene polymorphisms associated with arterial stiffness in healthy individuals?
Population
865 healthy individuals
Comparison
Presence of MMP-9 gene polymorphisms vs Absence of rare alleles for MMP-9 polymorphisms
Design
Cohort
Authors
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Should not change stiffness assessment in healthy adults; leaves open whether MMP-9 variants predict progression or guide interventions.
Are MMP-9 gene polymorphisms associated with arterial stiffness in healthy individuals?
Genetic variation in the MMP-9 gene is associated with increased aortic stiffness and elastase activity in healthy individuals, suggesting a genetic basis for large artery stiffening.
Yasmin et al. (2006) studied this question.
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